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Let the figures tell our story! I got an A on this project. Clin Genitourin Cancer. Epub Apr 1. Medical biotechnology as a paradigm for forest restoration and introduction of the transgenic American chestnut. Prevalence of co-existing autoimmune disease in juvenile idiopathic arthritis: a cross-sectional study. Cellular census of human fibrosis defines functionally distinct stromal cell types and states.

KLK6 expression in skin induces PAR1-mediated psoriasiform dermatitis and inflammatory joint disease. Indirect treatment comparison of nivolumab versus placebo for the adjuvant treatment of melanoma. Software-aided detection and structural characterization of cyclic peptide metabolites in biological matrix by high-resolution mass spectrometry. Current status and future directions of high-throughput ADME screening in drug discovery. Developing Biotherapeutics in the New Decade. Serum interleukin-6 and C-reactive protein are associated with survival in melanoma patients receiving immune checkpoint inhibition. Recommendations for singlet-based approach in ligand binding assays: an IQ Consortium perspective. Interplay of somatic alterations and immune infiltration modulates response to PD-1 blockade in advanced clear cell renal cell carcinoma.

Pharmacokinetics and tolerability of fedratinib, an oral, selective Janus kinase 2 inhibitor, in subjects with renal or hepatic impairment. Propensity score matching and inverse probability of treatment weighting to address confounding by indication in comparative effectiveness research of oral anticoagulants. Inoculum size and traits of the infecting clinical strain define the protection level against Mycobacterium tuberculosis infection in a rabbit model. Fedratinib in patients with myelofibrosis previously treated with ruxolitinib: An updated analysis of the JAKARTA2 study using stringent criteria for ruxolitinib failure.

Opportunities for use of one species for longer-term toxicology testing during drug development: A cross-industry evaluation. Health-related quality of life results from the IFM trial: treatment with lenalidomide, bortezomib, and dexamethasone in transplant-eligible patients with newly diagnosed multiple myeloma. A budget impact analysis for making treatment decisions based on anti-cyclic citrullinated peptide anti-CCP testing in rheumatoid arthritis. Infections in patients diagnosed with multiple sclerosis: A multi-database study. Achievement of red blood cell transfusion independence in red blood cell transfusion-dependent patients with lower-risk non-del 5q myelodysplastic syndromes correlates with serum erythropoietin levels.

The value of immunotherapy for survivors of stage IV non-small cell lung cancer: patient perspectives on quality of life. Nonhomologous end-joining repair is likely involved in the repair of double-stranded DNA breaks induced by riluzole in melanoma cells. Pharmacoecon Open. Hepatocyte spheroids as a viable in vitro model for recapitulation of complex in vivo metabolism pathways of loratadine in humans. Presence of anti-cyclic citrullinated peptide antibodies is associated with better treatment response to abatacept but not to TNF inhibitors in patients with rheumatoid arthritis: a meta-analysis. Clin Exp Rheumatol.

Core outcome set measurement for future clinical trials in acute myeloid leukemia: the HARMONY study protocol using a multi-stakeholder consensus-based Delphi process and a final consensus meeting. Sesquiterpenoids from Cultures of the Basidiomycetes Irpex lacteus. MDM Policy Pract. J Health Econ Outcomes Res. Germline variant burden in cancer genes correlates with age at diagnosis and somatic mutation burden. Corrigendum to "A systematic strategy for estimating hERG block potency and its implications in a new cardiac safety paradigm" [Toxicology and Applied Pharmacology volume C ].

Epub Apr 2. Retrospective observational cohort study on innovation in oncology and progress in survival: How far have we gotten in the two decades of treating patients with advanced non-small cell lung cancer as a single population? Symptom burden and its functional impact in patients with "symptomatic" relapsed or refractory multiple myeloma. Bridging size and charge variants of a therapeutic monoclonal antibody by two-dimensional liquid chromatography. Pomalidomide, dexamethasone, and daratumumab in relapsed refractory multiple myeloma after lenalidomide treatment.

A systematic strategy for estimating hERG block potency and its implications in a new cardiac safety paradigm. Response to "Letter to the Editor concerning: 'A systematic review of network meta-analyses among patients with nonvalvular atrial fibrillation: A comparison of efficacy and safety following treatment with direct oral anticoagulants'". Elevated serum interleukin-8 is associated with enhanced intratumor neutrophils and reduced clinical benefit of immune-checkpoint inhibitors. The Society for Immunotherapy of Cancer statement on best practices for multiplex immunohistochemistry IHC and immunofluorescence IF staining and validation.

Medicare Population. Viral contamination in biologic manufacture and implications for emerging therapies. A phase I study of the effect of repeated oral doses of pantoprazole on the pharmacokinetics of a single dose of fedratinib in healthy male subjects. Effects of repeated oral doses of ketoconazole on a sequential ascending single oral dose of fedratinib in healthy subjects. Epub Apr 4. Correction to: Evaluation of the bioequivalence and food effect on the bioavailability of CC oral azacitidine tablets in adult patients with cancer. Immunosuppression and the risk of readmission and mortality in patients with rheumatoid arthritis undergoing hip fracture, abdominopelvic and cardiac surgery. Accelerating the development of innovative cellular therapy products for the treatment of cancer.

Relationship between remission, disease activity and patient-reported outcome measures in patients with recent-onset systemic lupus erythematosus. Human papillomavirus type 16 infection activates the host serine arginine protein kinase 1 SRPK1 - splicing factor axis. Disruptive innovation in rheumatology: new networks of global public-private partnerships are needed to take advantage of scientific progress. Urelumab alone or in combination with rituximab in patients with relapsed or refractory B-cell lymphoma. Patient-reported outcome measures in studies of myelodysplastic syndromes and acute myeloid leukemia: Literature review and landscape analysis. A novel approach enables imaged capillary isoelectric focusing analysis of PEGylated proteins.

Effective temperature shift strategy development and scale confirmation for simultaneous optimization of protein productivity and quality in Chinese hamster ovary cells. Cost-effectiveness analysis of nivolumab for the treatment of squamous cell carcinoma of the head and neck in the United States. Covariate adjustment for randomized controlled trials revisited. Response to: Olry de Labry Lima A et al. Bone Marrow Transplant. J Invest Dermatol. Epub Nov 9. Characterizing heart failure with preserved and reduced ejection fraction: An imaging and plasma biomarker approach. Comparison of readmissions among hospitalized nonvalvular atrial fibrillation patients treated with oral anticoagulants in the United States.

Cancer Immunol Res. Comparative efficacy and safety of current therapies for early rheumatoid arthritis: a systematic literature review and network meta-analysis. Safety and effectiveness of non-vitamin K oral anticoagulants versus warfarin in real-world patients with non-valvular atrial fibrillation: a retrospective analysis of contemporary Japanese administrative claims data. Circulating and tissue matricellular RNA and protein expression in calcific aortic valve disease. Physiol Genomics. Cost-effectiveness of targeted screening for the identification of patients with atrial fibrillation: evaluation of a machine learning risk prediction algorithm. Iberdomide CC is a potent cereblon E3 ligase modulator with antitumor and immunostimulatory activities in lenalidomide- and pomalidomide-resistant multiple myeloma cells with dysregulated CRBN.

Abatacept retention and clinical outcomes in Austrian patients with rheumatoid arthritis: real-world data from the 2-year ACTION study. Wien Med Wochenschr. Microhomology-mediated end joining drives complex rearrangements and overexpression of MYC and PVT1 in multiple myeloma. Fast understanding of phases and phase separation in liquid crystal drug delivery systems using deuterium solid-state NMR. Solid State Nucl Magn Reson. Strategies for method comparison when changes in the immunogenicity method are needed within a clinical program. Interspecies prediction of pharmacokinetics and tissue distribution of doxorubicin by physiologically-based pharmacokinetic modeling.

The safety and pharmacokinetics of a novel, selective S1P1R modulator in healthy participants. Quality of life with second or third line nab -paclitaxel-based regimens in advanced non-small-cell lung cancer. Late-stage oxidative C sp 3 -H methylation. Enasidenib in patients with mutant IDH2 myelodysplastic syndromes: a phase 1 subgroup analysis of the multicentre, AGC trial.

The path to a better biomarker: application of a risk management framework for the implementation of PD-L1 and TILs as immuno-oncology biomarkers in breast cancer clinical trials and daily practice. Nonindependence of patient data in the clinical practice research datalink: a case study in atrial fibrillation patients. Collagen biology and non-invasive biomarkers of liver fibrosis. A gene immune, stromal and proliferation gene signature that significantly associates with poor survival in patients with pancreatic ductal adenocarcinoma.

Ann Oncol. Cross-site and cross-platform variability of automated patch clamp assessments of drug effects on human cardiac currents in recombinant cells. J Pharm Pract. Prevalence of chronic kidney disease in the community using data from OxRen: a UK population-based cohort study. Leveraging gene expression subgroups to classify DLBCL patients and select for clinical benefit from a novel agent. Triggers of Inflammatory Heart Disease. Single cell force profiling of human myofibroblasts reveals a biophysical spectrum of cell states. Clin Gastroenterol Hepatol.

Safety, pharmacokinetics and pharmacodynamics of branebrutinib BMS , a covalent, irreversible inhibitor of Bruton's tyrosine kinase: Randomised phase I, placebo-controlled trial in healthy participants. Role of wetting agents and disintegrants in development of danazol nanocrystalline tablets. Hum Immunol. Targeting the Wnt signaling pathway through R-spondin 3 identifies an anti-fibrosis treatment strategy for multiple organs.

Mol Ther Nucleic Acids. Mol Cell. A conserved intratumoral regulatory T cell signature identifies BB as a pan-cancer target. J Clin Invest. Hybrid mode of hydrophobic interaction chromatography of monoclonal antibodies and related biomolecules: Influence of elution conditions on chromatographic performance using poly alkyl aspartamide silica columns.

Survival, costs, and health care resource use by line of therapy in US Medicare patients with newly diagnosed glioblastoma: a retrospective observational study. Clin Colorectal Cancer. Letter to the Editor concerning "Bacteria: back pain, leg pain and Modic sign: a surgical multicenter comparative study" by Fritzell, P. Eur Spine J Understanding mAb aggregation during low pH viral inactivation and subsequent neutralization. Evaluation of the bioequivalence and food effect on the bioavailability of CC oral azacitidine tablets in adult patients with cancer. Epub Feb 8. CheckMate A phase 2 trial of nivolumab in patients with previously treated advanced squamous non-small cell lung cancer, including ECOG PS 2 and elderly populations. Nab-paclitaxel plus gemcitabine in patients with locally advanced pancreatic cancer LAPACT : a multicentre, open-label phase 2 study.

ILC2s amplify PD-1 blockade by activating tissue-specific cancer immunity. Comparative safety and efficacy of ozanimod versus fingolimod for relapsing multiple sclerosis. Kinetic modeling of Chinese hamster ovary cell culture: factors and principles. Crit Rev Biotechnol. Multiplex immunofluorescence staining and image analysis assay for diffuse large B cell lymphoma. Clinical outcomes with fixed-duration therapy UK real-world data compared with continuous lenalidomide and low-dose dexamethasone therapy FIRST trial; MM for transplant-ineligible patients with newly-diagnosed multiple myeloma. Evaluation of correlation between bioanalytical methods. Relative efficacy of treatment options in transplant-ineligible newly diagnosed multiple myeloma: results from a systematic literature review and network meta-analysis.

Does recall period matter? A Bayesian zero-inflated binomial regression and its application in dose-finding study. Dasatinib discontinuation in patients with chronic-phase chronic myeloid leukemia and stable deep molecular response: the DASFREE study. New Technologies to Image Tumors. Approaches for machine learning intermolecular interaction energies and application to energy components from symmetry adapted perturbation theory.

Differential RNA splicing as a potentially important driver mechanism in multiple myeloma. Effect of restricted dissolved oxygen on expression of Clostridium difficile toxin A subunit from E. Orally bioavailable amine-linked macrocyclic inhibitors of factor XIa. Epub Jan 7. Gastrointestinal bleeding and the risk of colorectal cancer in anticoagulated patients with atrial fibrillation. A pharmaceutical industry perspective on microphysiological kidney systems for evaluation of safety for new therapies.

Microphysiological systems for ADME-related applications: current status and recommendations for system development and characterization. Integrative network modeling reveals mechanisms underlying T cell exhaustion. An amide-based sulfenamide prodrug of gamma secretase inhibitor BMS delivers parent drug from an oral conventional solid dosage form in male beagle dog. Heterocycle amide isosteres: An approach to overcoming resistance for HIV-1 integrase strand transfer inhibitors. Model-based evaluation of the efficacy and safety of nivolumab once every 4 weeks across multiple tumor types.

Pomalidomide plus low-dose dexamethasone in relapsed refractory multiple myeloma after lenalidomide treatment failure. Adverse events associated with weight-based, high-dose montelukast exposures in children. Clin Toxicol Phila. Epub May 6. No abstract available. Erratum in: Clin Toxicol Phila. Association among anti-citrullinated protein antibody status, erosive disease and healthcare resource utilization in patients with rheumatoid arthritis. Validation of obesity coding among newly treated nonvalvular atrial fibrillation patients using an integrated electronic medical record and claims database.

Implementing robotic surgery for uterine cancer in the United States: Better outcomes without increased costs. Comparison of inpatient admission rates of patients treated with apixaban vs. Pharmacokinetics and safety of apremilast in pediatric patients with moderate to severe plaque psoriasis: Results from a phase 2 open-label study. Current treatment patterns and medical costs for multiple myeloma in Japan: a cross-sectional analysis of a health insurance claims database. Real-world treatment patterns, cost of care and effectiveness of therapies for patients with squamous cell carcinoma of head and neck pre and post approval of immuno-oncology agents. Pirfenidone in patients with unclassifiable progressive fibrosing interstitial lung disease: a double-blind, randomised, placebo-controlled, phase 2 trial.

Immunotherapy rechallenge after nivolumab treatment in advanced non-small cell lung cancer in the real-world setting: A national data base analysis. Real-world effectiveness and safety of nivolumab in patients with non-small cell lung cancer: A multicenter retrospective observational study in Japan. Absolute lymphocyte count as a prognostic biomarker for overall survival in patients with advanced melanoma treated with ipilimumab. From single-arm studies to externally controlled studies. Methodological considerations and guidelines. Acceptability and content validity of patient-reported measures considered from the rheumatoid arthritis patient's perspective.

Print Stability behaviour of antiretroviral drugs and their combinations. Bleeding and recurrent VTE with apixaban vs warfarin as outpatient treatment: time-course and subgroup analyses. Decoding the small size challenges of mini-tablets for enhanced dose flexibility and micro-dosing. Chem Res Toxicol. Use of Zebrafish in Drug Discovery Toxicology. Liver microphysiological systems development guidelines for safety risk assessment in the pharmaceutical industry. Can real-world data really replace randomised clinical trials? Applications of fluorine-containing amino acids for drug design. Epub Nov 4. Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification.

Application of in-sample calibration curve methodology for regulated bioanalysis: Critical considerations in method development, validation and sample analysis. Design, synthesis and biological evaluation of phenol-linked uncialamycin antibody-drug conjugates. Biomanufacturing evolution from conventional to intensified processes for productivity improvement: a case study. Consensus guidelines: best practices for detection, assessment and management of suspected acute drug-induced liver injury occurring during clinical trials in adults with chronic cholestatic liver disease. Epub Dec 1. Treatment patterns and healthcare costs among biologic-naive patients initiating apremilast or biologics for the treatment of psoriatic arthritis: results from a US claims analysis.

Application of the adverse outcome pathway framework to genotoxic modes of action. Potential of machine learning methods to identify patients with nonvalvular atrial fibrillation. Correction to: Developing real-world comparators for clinical trials in chemotherapy-refractory patients with gastric cancer or gastroesophageal junction cancer. Developing real-world comparators for clinical trials in chemotherapy-refractory patients with gastric cancer or gastroesophageal junction cancer. Gastric Cancer. Erratum in: Gastric Cancer.

Clinical and economic outcomes of treatment sequences for intermediate- to poor-risk advanced renal cell carcinoma. Left atrial ejection fraction and outcomes in heart failure with preserved ejection fraction. Int J Cardiovasc Imaging. Elotuzumab plus lenalidomide and dexamethasone for newly diagnosed multiple myeloma: a randomized, open-label, phase 2 study in Japan. Incidence of seroconversion and sero-reversion in patients with multiple sclerosis MS who had been treated with natalizumab: A systematic review and meta-analysis. Comparative effectiveness of nivolumab versus clinical practice for advanced gastric or gastroesophageal junction cancer. Therapeutic inertia in the management of moderate-to-severe plaque psoriasis.

J Eur Acad Dermatol Venereol. Epub Sep 2. A simplified frailty scale predicts outcomes in transplant-ineligible patients with newly diagnosed multiple myeloma treated in the FIRST MM trial. Incident cardiovascular disease in patients diagnosed with multiple sclerosis: A multi-database study. Analysis of historical negative control group data from the rat in vivo micronucleus assay. Design and characterization of mouse IgG1 and IgG2a bispecific antibodies for use in syngeneic models. Design of next-generation therapeutic IgG4 with improved manufacturability and bioanalytical characteristics.

Optimization and kinetic modeling of interchain disulfide bond reoxidation of monoclonal antibodies in bioprocesses. On-column disulfide bond formation of monoclonal antibodies during Protein A chromatography eliminates low molecular weight species and rescues reduced antibodies. Enabling speed to clinic for monoclonal antibody programs using a pool of clones for IND-enabling toxicity studies.

Investigation of anomalous charge variant profile reveals discrete pH-dependent conformations and conformation-dependent charge states within the CDR3 loop of a therapeutic mAb. Recent advances and optimal management of human epidermal growth factor receptorpositive early-stage breast cancer. Pegbelfermin BMS , a PEGylated fibroblast growth factor 21 analogue, in patients with non-alcoholic steatohepatitis: a randomised, double-blind, placebo-controlled, phase 2a trial.

Inflammatory bowel disease - one entity with many molecular faces. Prz Gastroenterol. Cancer diagnosis and care among rural-to-urban migrants in China. Appl Health Econ Health Policy. Practical applications of bio-fluorescent particle counting in Environmental Monitoring investigations. Adverse vacuolation in multiple tissues in cynomolgus monkeys following repeat-dose administration of a PEGylated protein. An analysis of orphan medicine expenditure in Europe: is it sustainable? Clin Breast Cancer. Galectindriven T cell exclusion in the tumor endothelium promotes immunotherapy resistance.

A generic method for intact and subunit level characterization of mAb charge variants by native mass spectrometry. Exploratory biomarker assays: key assay parameters to evaluate in the face of evolving biomarker context-of-use. Safety, effectiveness, and health care cost comparisons among elderly patients with venous thromboembolism prescribed warfarin or apixaban in the United States Medicare population.

Curr Med Res Opin. Epub Sep 3. Chemical and physical instabilities in manufacturing and storage of therapeutic proteins. Curr Opin Biotechnol. Epub Mar 9. Early Access to Medicines Scheme: real-world data collection. Report of the European Society of Cardiology Cardiovascular Round Table regulatory workshop update of the evaluation of new agents for the treatment of acute coronary syndrome: Executive summary. Phase II study of CC oral azacitidine in previously treated patients with locally advanced or metastatic nasopharyngeal carcinoma.

Considering B7-CD28 as a family through sequence and structure. Exp Biol Med Maywood. Lenalidomide maintenance post-transplantation in newly diagnosed multiple myeloma: real-world outcomes and costs. Improving health determinants outside of the clinic does not mean outside of clinical science. Healthc Amst. J Am Soc Mass Spectrom. Apremilast mechanism of efficacy in systemic-naive patients with moderate plaque psoriasis: Pharmacodynamic results from the UNVEIL study.

Qualitative analysis and reproducibility assessment of the Scalp Itch Numeric Rating Scale among patients with moderate to severe plaque psoriasis of the scalp. Corrigendum to "Nivolumab in advanced hepatocellular carcinoma: Sorafenib-experienced Asian cohort analysis" [J Hepatol 71 ]. Total costs of treating venous thromboembolism: implication of different cost perspectives in a Danish setting. Immunotargeted therapy in melanoma: patient, provider preferences, and willingness to pay at an academic cancer center.

Expedited mapping of the ligandable proteome using fully functionalized enantiomeric probe pairs. Parameter estimation for roller compaction process using an instrumented vector TF mini roller compactor. Epub Sep 9. Comparative safety of abatacept in rheumatoid arthritis with COPD: A real-world population-based observational study. Semin Arthritis Rheum. Identification of novel glutathione conjugates of terbinafine in liver microsomes and hepatocytes across species. Protein aggregation and mitigation strategy in low pH viral inactivation for monoclonal antibody purification. Process intensification in fed-batch production bioreactors using non-perfusion seed cultures.

Determinants of treatment in patients with stage IV renal cell carcinoma. Lipid order and charge protect killer T cells from accidental death. Epub Oct 8. Epub Oct 1. Age at menarche and risk of multiple sclerosis MS : a systematic review and meta-analysis. Clinical outcomes and treatment patterns among Medicare patients with nonvalvular atrial fibrillation NVAF and chronic kidney disease. Tumor mutational burden in lung cancer: a systematic literature review. Comparative risk of malignancies and infections in patients with rheumatoid arthritis initiating abatacept versus other biologics: a multi-database real-world study. Assay Guidance Manual [Internet]. Predicting atrial fibrillation in primary care using machine learning.

Abatacept retention and clinical outcomes in rheumatoid arthritis: real-world data from the German cohort of the ACTION study and a comparison with other participating countries. Adults: A Cost-effectiveness Analysis. Characterization of therapeutic antibody fragmentation using automated capillary western blotting as an orthogonal analytical technique. Safety and efficacy of nivolumab in challenging subgroups with advanced melanoma who progressed on or after ipilimumab treatment: A single-arm, open-label, phase II study CheckMate Suspected cancer symptoms and blood test results in primary care before a diagnosis of lung cancer: a case-control study.

Comparison of accelerometer-derived physical activity levels between individuals with and without cancer: a UK Biobank study. Automated extraction of treatment patterns from social media posts: an exploratory analysis in renal cell carcinoma. Japanese real-world study of sequential nivolumab and ipilimumab treament in melanoma. Economic modeling to evaluate the impact of chronic myeloid leukemia therapy management on the oncology care model in the US. Increasing value of autopsies in patients with brain tumors in the molecular era. Human or mouse? Practice makes perfect. Erratum in: Lancet Oncol.

Elucidating spray-dried dispersion dissolution mechanisms with focused beam reflectance measurement: contribution of polymer chemistry and particle properties to performance. Randomized phase-II evaluation of letrozole plus dasatinib in hormone receptor positive metastatic breast cancer patients. The hepatoprotective activities of Kalimeris indica ethanol extract against liver injury in vivo. PLoS One. Erratum in: PLoS One. Benzothiazole-based compounds as potent endothelial lipase inhibitors. Epub Sep 6. Structure based design of macrocyclic factor XIa inhibitors: Discovery of cyclic P1 linker moieties with improved oral bioavailability. Allogeneic murine pregnancy models for assessing the developmental effects of immune-stimulating antibodies: Challenges in reproducibility.

Stereospecific interactions between histidine and monoclonal antibodies. Control of antibody high and low molecular weight species by depth filtration-based cell culture harvesting. The effects of buffer condition on the fouling behavior of MVM virus filtration of an Fc-fusion protein. Continuation with apixaban treatment is associated with lower risk for hospitalization and medical costs among elderly patients. Epub Jun 5. Developments in the treatment of HCV genotype 3 infection. Expert Rev Anti Infect Ther. Immune checkpoint inhibition in sepsis: a Phase 1b randomized study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of nivolumab.

Systematic review of societal costs associated with stroke, bleeding and monitoring in atrial fibrillation. Patient characteristics and stroke and bleeding events in nonvalvular atrial fibrillation patients treated with apixaban and vitamin K antagonists: a Spanish real-world study. Electrostatic-field and surface-shape similarity for virtual screening and pose prediction. J Comput Aided Mol Des. Nivolumab plus ipilimumab versus sunitinib in first-line treatment for advanced renal cell carcinoma: extended follow-up of efficacy and safety results from a randomised, controlled, phase 3 trial.

Four-year survival with nivolumab in patients with previously treated advanced non-small-cell lung cancer: a pooled analysis. Concordance of hospitalizations between Clinical Practice Research Datalink and linked Hospital Episode Statistics among patients treated with oral antidiabetic therapies. Exposure assessments in reproductive and developmental toxicity testing: An IQ-DruSafe industry survey on current practices and experiences in support of exposure-based high dose selection. Genetic toxicology in silico protocol. Comparison of immune system development in nonclinical species and humans: Closing information gaps for immunotoxicity testing and human translatability. Reprod Toxicol. Comparative electrophysiology and pharmacology of hiPSC cardiomyocyte 2D mono-cultures and 2D co-cultures with human ventricular fibroblasts.

Evaluating the use of microelectrode array technology and cell-based neuronal culture models for proconvulsant risk assessment: progress from the HESI NeuTox consortium. Characterization of a renal hypertensive model in telemetrized cynomolgus monkeys. Characterization of contractile properties of hIPSC-CMs cultured with or without fibroblast and chronic electrical stimulation. Mechanistic modeling based process development for monoclonal antibody monomer-aggregate separations in multimodal cation exchange chromatography. Metabolomic adaptations and correlates of survival to immune checkpoint blockade. Comparing record linkage software programs and algorithms using real-world data. Rapid, direct, and sensitive determination of aziridine and 2-chloroethylamine by hydrophilic interaction liquid chromatography-mass spectrometry.

Cost-effectiveness of apixaban compared to other anticoagulants in patients with atrial fibrillation in the real-world and trial settings. Nivolumab treatment beyond RECIST-defined progression in recurrent or metastatic squamous cell carcinoma of the head and neck in CheckMate A subgroup analysis of a randomized phase 3 clinical trial. A note on the empirical Bayes heterogeneity variance estimator in meta-analysis. JAMA Oncol.

Validity of social media for assessing treatment patterns in oncology patients: a case study in melanoma. Emerging biomaterials for downstream manufacturing of therapeutic proteins. Arthritis Care Res Hoboken. Best practices in bioassay development to support registration of biopharmaceuticals. Virus clearance validation across continuous capture chromatography. Suitability of a generic virus safety evaluation for monoclonal antibody investigational new drug applications.

Evaluation of covariate effects on pharmacokinetics of monoclonal antibodies in oncology. Epub Aug 7. Safety and efficacy of nivolumab in patients with rare melanoma subtypes who progressed on or after ipilimumab treatment: a single-arm, open-label, phase II study CheckMate Adjuvant ipilimumab versus placebo after complete resection of stage III melanoma: long-term follow-up results of the European Organisation for Research and Treatment of Cancer double-blind phase 3 randomised trial. In vivo models and decision trees for formulation development in early drug development: A review of current practices and recommendations for biopharmaceutical development.

Nivolumab in patients with unresectable locally advanced or metastatic urothelial carcinoma: CheckMate 2-year global and Japanese patient population analyses. Commonly used definitions in real-world studies may underestimate the prevalence of renal disease among nonvalvular atrial fibrillation patients. Nivolumab in advanced hepatocellular carcinoma: Sorafenib-experienced Asian cohort analysis. Epub Jun 7. Erratum in: J Hepatol.

Deuterated active pharmaceutical ingredients: A science-based proposal for synthesis, analysis, and control. Part 1: Framing the problem. Neoadjuvant letrozole plus taselisib versus letrozole plus placebo in postmenopausal women with oestrogen receptor-positive, HER2-negative, early-stage breast cancer LORELEI : a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial.

Efficacy and safety of first-line carboplatin-versus cisplatin-based chemotherapy for non-small cell lung cancer: A meta-analysis. Safety and effectiveness of abatacept in Japanese non-elderly and elderly patients with rheumatoid arthritis in an all-cases post-marketing surveillance. Hindered dialkyl ether synthesis with electrogenerated carbocations. Nivolumab versus investigator's choice in patients with recurrent or metastatic squamous cell carcinoma of the head and neck: Efficacy and safety in CheckMate by age.

Cost per response for abatacept versus adalimumab in patients with seropositive, erosive early rheumatoid arthritis in the US, Germany, Spain, and Canada. Overview and considerations for the reporting of clinical pathology interpretations in nonclinical toxicology studies. Interpretative considerations for clinical pathology findings in nonclinical toxicology studies. Treatment sequences for advanced renal cell carcinoma: A health economic assessment. Blood-brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy. Nat Commun. Erratum in: Nat Commun.